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Efficacy and safety of ravulizumab in adults with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: outcomes from the phase 3 CHAMPION-NMOSD trial

Author:Pittock, Sean   Barnett, Michael   Bennett, Jeffrey   Berthele, Achim   de Sèze, Jérôme   Levy, Michael   Nakashima, Ichiro   Oreja Guevara, Celia   Palace, Jacqueline   Paul, Friedemann   Pozzilli, Carlo   Allen, Kerstin   Mashhoon, Yasmin   Yountz, Marcus   Kim, Ho Jin   

Session Name:S5: Autoimmune Neurology: NMOSD and MG, A Focus on Treatment Trials  

Topic:Autoimmune Neurology  

Program Number:S5.002  

Author Institution:Department of Neurology, Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA, Rochester, MN  Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia  Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, Australia, Camperdown, Australia  Departments of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado, Aurora, CO, USA, Aurora, CO  Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany, Muenchen, Germany  Department of Neurology and Clinical Investigation Center, CHU de Strasbourg, Strasbourg, France, Strasbourg, France  Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA  Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan  Division of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, Sendai, Japan  Department of Neurology, Hospital Clínico Universitario San Carlos, IdISCC, Madrid, Spain  Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Madrid, Spain  Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK, Oxford, United Kingdom  Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany  Department of Human Neuroscience, University Sapienza, Rome, Italy, Rome, Italy  Alexion, AstraZeneca Rare Disease, Boston, MA, USA, Boston, MA  Alexion, AstraZeneca Rare Disease, Boston, MA, USA, Watertown, MA  Alexion, AstraZeneca Rare Disease, Boston, MA, USA *At the time this research was conducted., Needham, MA  Department of Neurology, National Cancer Center, Goyang, South Korea, Goyang, Korea, Republic of  

Efficacy subgroup analyses from the phase 3 CHAMPION-NMOSD trial in adults with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder

Author:Levy, Michael   Pittock, Sean   Barnett, Michael   Bennett, Jeffrey   Berthele, Achim   De Seze, Jerome   Nakashima, Ichiro   Oreja Guevara, Celia   Palace, Jacqueline   Paul, Friedemann   Pozzilli, Carlo   Allen, Kerstin   Mashhoon, Yasmin   Yountz, Marcus   Kim, Ho Jin   

Session Name:S5: Autoimmune Neurology: NMOSD and MG, A Focus on Treatment Trials  

Topic:Autoimmune Neurology  

Program Number:S5.003  

Author Institution:Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA  Department of Neurology, Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA, Rochester, MN  Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia  Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, Australia, Camperdown, Australia  Departments of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado, Aurora, CO, USA, Aurora, CO  Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany, Muenchen, Germany  Department of Neurology and Clinical Investigation Center, CHU de Strasbourg, France, Strasbourg, France  Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan  Division of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, Sendai, Japan  Department of Neurology, Hospital Clínico Universitario San Carlos, IdISCC, Madrid, Spain  Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Madrid, Spain  Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK, Oxford, United Kingdom  Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany  Department of Human Neuroscience, University Sapienza, Rome, Italy, Rome, Italy  Alexion, AstraZeneca Rare Disease, Boston, MA, USA, Boston, MA  Alexion, AstraZeneca Rare Disease, Boston, MA, USA, Watertown, MA  Alexion, AstraZeneca Rare Disease, Boston, MA, USA *At the time this research was conducted., Needham, MA  Department of Neurology, National Cancer Center, Goyang, South Korea, Goyang, Korea, Republic of